A beta version of life: p110β takes center stage
نویسندگان
چکیده
منابع مشابه
A beta version of life: p110β takes center stage
The PI3K pathway is frequently activated in tumors, most commonly through p110α mutation or PTEN deletion. In contrast to p110α, p110β is oncogenic when over-expressed in the wild-type state, suggesting that its regulation by p85 is different than that of p110α. In this perspective, we summarize recent data concerning the regulation of p110β, which shows that wild-type p110β acts like an oncoge...
متن کاملLeukemia takes center (late) stage.
on the activated platelets can bind PSGL-1, strengthening the association between the activated neutrophil microparticle and the platelets. It has been previously established that GPIb directly binds activated leukocyte Mac-1,5 as well as P-selectin expressed on activated platelets/endothelial cells,3,6 enabling GPIb -mediated plateletleukocyte-endothelial cell crosstalk; for example, platelets...
متن کاملCancer epigenetics takes center stage.
N year will mark 20 years since I developed a Southern blot showing altered DNA methylation in cancer. This discovery (1) was met with some skepticism, primarily because it was thought that aberrant methylation in cancer was an epiphenomenon, somehow linked to a generalized disruption of gene regulation in cancer cells and arising after the cancer, rather than playing a causal role itself. This...
متن کاملNeuroimmunology of stress: skin takes center stage.
Like few other organs, the skin is continuously exposed to multiple exogenous and endogenous stressors. Superimposed on this is the impact of psychological stress on skin physiology and pathology. Here, we review the "brain-skin connection," which may underlie inflammatory skin diseases triggered or aggravated by stress, and we summarize relevant general principles of skin neuroimmunology and n...
متن کاملCytokinesis: The Central Spindle Takes Center Stage
The central spindle plays a key role in cytokinesis. Recent studies have shed new light on how assembly of the central spindle is regulated, and also support a role for both the central spindle and astral microtubules in cytokinesis in animal cells.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2010
ISSN: 1949-2553
DOI: 10.18632/oncotarget.207